Simple answer: d-alpha or the full spectrum of tocopherols and tocotrienols.
I recommend the Metagenics E Complex-1:1™. It is a pure, unesterified vitamin E formula that features d-alpha tocopherol combined with a mixed tocopherol blend, achieving a one-to-one ratio of alpha to gamma tocopherols. This unique formula is designed to provide the antioxidant benefits that come from consuming a comprehensive family of tocopherols.
- Vitamin E inhibits protein kinase C activity, which supports cellular health in several types, including smooth, muscle, platelets, and monocytes.*
- Delivers an especially powerful blend of different tocopherols for a broader range of antioxidant protection against the ravages of free radicals.*
- Provides balanced levels of gamma- and alpha-tocopherols that are more closely associated with consumption of vitamin E-rich foods.*
- Provides gamma-tocopherol for unique antioxidant protection.*
Purchase at : http://drjeffreytucker.com and click on Metagenics
Researchers from Harvard took blood samples from about 3,000 subjects and measured omega-3 levels. When the results were compared to diabetic status, they found that higher levels of omega-3 fatty acids — EPH and DHA — were linked to reduced risk of diabetes.
Rrisk was lowest in those with the highest omega-3 levels. The is because EPA and DHA help your cell membranes manage insulin. Fat tissue contains an abundance of macrophages — a type of white blood cell that fights viruses, bacteria, and other junk that has to be removed from your cells. The macrophages do their work by producing proteins that burn off the junk with inflammation. Too much body fat creates a flood of those proteins, which happen to promote insulin resistance. Chronic inflammation just makes the situation worse.
When excessive inflammation is reduced, insulin sensitivity improves.
EPA and DHA are great natural anti-inflammatories. For the past year or soI have recommended that patient’s take about 400 IU vitamin E with the omega 3’s (mixed tocopherols).
Researchers at Finland’s University of Helsinki examined many years of data collected on more than 10,800 subjects. Their first conclusion: Vitamin E has no effect on mortality.
But when they looked at specific sub-groups, one group stood out:
Lifespan was extended by two years in more than 2,280 men who used vitamin E supplements, and also had a higher than average vitamin C intake, smoked less than a pack of cigarettes per day, and were at least 71 years old. If you smoke and you think a little vitamin E pill is supposed to undo that damage, you are crazy!
But the fact that “Lifespan was extended by two years”…I’m impressed!
If you take a daily E to help control free radical damage throughout your body, that is a smart step toward living healthier. An E supplement is also likely to help keep your heart healthy, reduce stroke risk, enhance your immune system, and maintain a healthy prostate.
Mainstream medicine has not been kind to vitamin E in the press lately so I wanted to make sure you understand the truth.
Eating food rich in vitamin E may reduce the risk of developing dementia, while insufficient levels of vitamin D may increase the risk of cognitive decline, say two new studies.
Archives of Neurology 67(7):819-825, 2010
Archives of Internal Medicine 170(13):1135-1141, 2010
People who consumed the highest average intakes of vitamin E from the diet were 25% less likely to develop dementia than people with the lowest average intakes, according to new data published in the Archives of Neurology.
Scientists from the Erasmus Medical Center in Rotterdam, the Netherlands, postulated that the benefits were related to the antioxidant activity of vitamin E, which counters the oxidative stress induced by a buildup of beta-amyloid protein.
The buildup of plaque from beta-amyloid deposits is associated with an increase in brain cell damage and death from oxidative stress. This is related to a loss of cognitive function and an increased risk of Alzheimer’s, the most common form of dementia that currently affects over 13 million people worldwide.
In another study from a Swedish study, published in the Journal of Alzheimer’s Disease, which found that a combination of different vitamin E forms could help prevent cognitive deterioration in advanced age.
There are eight forms of vitamin E: Four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the most common form in the American diet.
Tocotrienols are only minor components in plants, although several sources with relatively high levels include palm oil, cereal grains and rice bran.
For the new study, the Rotterdam-based scientists analyzed data on the intakes of antioxidants—vitamins C and E, beta-carotene and flavonoids—in 5,395 people aged 55 and older. Questionnaires and meal-based checklists were used to establish intakes of these micronutrients.
The participants were followed for about 10 years, during which 465 people developed dementia, of which 365 cases were for Alzheimer’s disease.
After crunching the numbers, the researchers calculated that people with an average intake of 18.5 mg of vitamin E per day were 25% less likely to develop dementia than the people with an average of 9 mg per day. On the other hand, no associations were observed for dietary intake levels of vitamin C, beta-carotene and flavonoids.
“The brain is a site of high metabolic activity, which makes it vulnerable to oxidative damage, and slow accumulation of such damage over a lifetime may contribute to the development of dementia,” wrote the authors.
“In particular, when beta-amyloid (a hallmark of pathologic Alzheimer’s disease) accumulates in the brain, an inflammatory response is likely evoked that produces nitric oxide radicals and downstream neurodegenerative effects. Vitamin E is a powerful fat-soluble antioxidant that may help to inhibit the pathogenesis of dementia.”
The current issue of the Archives of Internal Medicine also carries new data from British researchers who report that seniors with low levels of vitamin D may be at an increased risk of cognitive decline.
Our cognitive performance declines naturally as we age, but new data from David Llewellyn and his colleagues at the University of Exeter in England indicates that insufficient levels of vitamin D may accelerate this decline.
The Exeter-based scientists analyzed vitamin D levels from blood samples of 858 adults aged 65 and older. Cognitive tests were undertaken at the start of the study, and again after three and six years.
The data showed that severe vitamin D deficiency, defined as blood levels of 25-hydroxyvitamin D (25(OH)D) of less than 25 nanomoles per liter—were associated with a 60% increase in the risk of substantial cognitive decline.
“If future prospective studies and randomized controlled trials confirm that vitamin D deficiency is causally related to cognitive decline, then this would open up important new possibilities for treatment and prevention,” concluded Llewellyn and his co-workers.
The best answer is to improve your overall diet & provide supportive supplements. High amounts of glucose cross-bind with protein molecules in the vascular system resulting in plaque formation. Therefore, the diet needs to be low in simple sugars, but high in complex carbohydrates such as vegetables. A Paleo-Mediterranean approach with high fiber is one approach I have seen work. You have to trust that the latest research continues to shown that a low glycemic diet is more effective than a low fat diet.
The supportive supplements from Metagenics would include:
Wellness Essentials™ formula — 2 packets daily. These include the key vitamins & minerals and essential fatty acids.
Cardiogenics Intensive Care — 2 tablets twice daily between meals. Cardiogenics Intensive Care is a comprehensive heart muscle support formula that features extracts of hawthorn and arjuna with a history of traditional use supporting the heart, possibly by helping to maintain blood vessel dilation and healthy blood pressure already within the normal range. Complementing these herbs is a blend of amino acids and minerals—including magnesium, potassium, and calcium—that play important roles in heart muscle function.
E-Complex 1:1 — 2-4 softgels daily with meals. E-Complex-1:1 is a unique, natural vitamin E supplement that features a 1:1 ratio of alpha- to gamma-tocopherol; this ratio more closely resembles the tocopherol profile found naturally in vitamin E-rich plants.
EPA/DHA 720 — 2 softgels 2-3 times daily with meals. Studies indicate that omega-3 fatty acids (EPA-DHA) may protect against decreases in cerebral blood flow and cerebral edema in the presence of an acute carotid occlusion. ltraMeal® Plus 360° — 2 scoops twice daily. UltraMeal® Plus 360° is a medical food formulated to provide specialized, multi-mechanistic nutritional support for patients with metabolic syndrome and cardiovascular disease by supplying a combination of acacia extract, reduced iso-alpha acids (RIAA), plant sterols, and heart-healthy soy protein and isoflavones. UltraMeal is used in treating obesity, insulin resistance, dyslipidemia, cardiovascular disease and type 2 diabetes.
High Concentrate EPA-DHA Liquid™ — 1 tsp. twice daily. High Concentrate EPA-DHA Liquid provides at least 2,800 mg per serving of EPA, DHA, and other puritycertified, omega-3 essential fatty acids in triglyceride form.
Mag Glycinate™ – 2 tablets twice daily with meals.
ORDER supplements at www.DrJeffreyTucker.meta-ehealth.com
A consistent exercise program will need to be incorporated into your life.