All Posts tagged vitamin D3

Atherosclerosis & Vitamin D

Atherosclerosis is still responsible for the highest number of deaths in the U.S. Approximately one million people die from the disease each year. In one article I read it said atherosclerosis is the leading killer of both men and women after the age of 46.

Atherosclerosis, a type of arteriosclerosis, is a condition in which fatty material (plaque) collects along the walls of arteries and as this fatty material thickens, and hardens it may eventually block arteries. Over time, the plaque can make the artery narrow and less flexible. In essence the artery becomes stiff.

A group of researchers now believes that vitamin D deficiency may play a role in causing the problem. In fact, they find that reduced levels of vitamin D appear to correlate with increased arterial stiffness.

I still recommend 2-3,000 IU of vitamin D 3 per day and make sure that you do some stretching. There is evidence that whole body stretching is helpful to reduce arterial stiffness.

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Vitamin D3 & Bone Health

The Interactive Healer
DrJeffreyTucker.com 

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July 30, 2010 

 

 
In This Issue
Dr. Tucker’s New E-Book Released!
Vitamin D
Improve Posture
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Dear Dr. Jeff,
Dr. Jeffrey Tucker

This week’s newsletter offers you tips for when to take vitamin D, as well as supplements for osteoporosis and important exercises for maintaining good posture. 
Keep checking www.DrJeffreyTucker.com so I can keep you updated on important and valuable health information. 
If you have any questions, suggestions or comments, please feel free to email Dr. Tucker at:  DrJTucker@aol.com

 

Posture and Mobility: Nine Steps to Assessing and Improving Your Health available – order now!

 

I am proud to announce the release of my e-book Posture and Mobility: Nine Steps to Assessing and Improving Your Health. Using self-assessment tests, you are guided through a progressive and safe format to increase your strength, range of motion, power and endurance. If you have been searching for a way to increase physical, optimal health, this book will help you.
 
Order directly from Lulu.com and have this professionally-bound book delivered to your door for $37.75 or download the book electronically for only $18.75.
 

Osteoporosis & Ostera 

 

Ostera (a natural supplement from Metagenics) versus the new crop of osteoporosis drugs such as denosumab. Let’s see: 
Denosumab is given by injection
Denosumab may cost more than $10,000 per year
Denosumab works by affecting the immune system, so the long-term effects on immune function and cancer risk are unknown and will need to be tracked by the FDA.

Or would you rather try something less-expensive and drug- free?

 

Ostera! A supplement that promotes healthy bone remodeling in postmenopausal women. Researchers at Metaproteomics, a nutrigenomic research and development company employing more than 40 scientists and physicians at its research centers in the US and Europe, developed Ostera. Drawing on the anti-inflammatory properties of hops, as well as other unique nutritional agents like berberine and acacia, Ostera is a potent promoter of bone-remodeling.

 

Osteoporosis is actually an INFLAMMATORY DISEASE. Inflammation accelerates bone loss. But all of us tend toward inflammation as we age, and this body-wide process does not exempt the bones. The realization that inflammation is at the core of osteoporosis has prompted investigation into new drug therapies that specifically target bone inflammation. One such drug is denosumab, now in clinical trials. Denosumab is a breakthrough bio-engineered monoclonal antibody. This new Amgen drug has shown significant benefits in clinical trials, and promises to be a block-buster once it’s approved within a couple of years. But it’s certain to be VERY expensive, and it requires injections to work. I predict these new drugs will arrive at an opportune time: just when the medical establishment and the public will be in full retreat from the current crop of medications, as their limitations and side effects become increasingly evident. 

 

Ostera, in combination with a Mediterranean-style, low-glycemic-load diet and aerobic exercise, has been clinically shown in postmenopausal women to beneficially influence key biomarkers of bone remodeling more than diet and exercise alone.

 
When Ostera was field-tested on 77 postmenopausal women with low estrogen. It produced dramatic improvements (greater than 40%) in markers of bone turnover. Those patients adding Ostera to there arsenal of natural therapies for osteoporosis will further enhance there results, sometimes even after a few short months of treatment. 
Ostera is perfectly safe with other natural supplements and prescribed medications.
Dr. Tucker’s osteoporosis recommendation: 
Cal Apatite Forte Capsules  Daily supplements of vitamin D and calcium.
Ostera A safe natural alternative for bone support.
Sources:
“Studies: New Osteoporosis Drug Cuts Fracture Risk” Linda A. Johnson, Associated Press, 8/11/09, ap.org

 

More on Vitamin D…

 

Vitamin D intake is important for muscle function, bone health, fighting cancer, improving heart health, and preventing type 2 diabetes. That’s why I think more is better… 
The International Osteoporosis Foundation supports raising the recommended daily intake of vitamin D to:
1) Daily intake of 800 to 1,000 IU
2) Daily intake of 2,000 for those who have osteoporosis, get limited sun exposure, or are obese.

This higher dosage is absolutely a step in the right direction, but it’s just starting to approach the daily D intake I recommend – between 2,000 and 3,000 IU daily, and 5,000 IU daily for those over the age of 40. 

Wake Forest University researchers examined data from a study that measured blood levels of D in more than 2,780 elderly subjects. Three blood samples were taken from each subject over the course of four years. Results showed that higher blood levels of D were linked to better physical function, while about 90 percent of subjects with the lowest D levels had poorer physical function. 

TIP: You may be able to significantly boost your vitamin D levels by following one simple habit: Take D supplements with your largest meal of the day. Researchers at the Cleveland Clinic Foundation Bone Clinic recruited 17 subjects who had remained vitamin D deficient even after being treated for their deficiency.

For 2-3 months, each subject began taking their D supplements with the largest meal of the day. Dosage levels varied from 1,000 to 50,000 IU daily.

Results: Overall, absorption of the vitamin was improved and blood levels of D increased by more than 50 percent when D was taken at a meal. 

Take Home Point: Take vitamin D supplements at lunch or dinner time.

 

I recommend Iso D3. Either the 2000 IU or 5000 IU depending on age and exposure to sunshime. Iso D3 is the preferred form of vitamin D3 with Isoflavones.

 

 

These exercises prevent the natural progression of kyphosis (rounded back)

Rounded shoulders & slumped posture increases in healthy men & women with age, with the most rapid increase occurring between 50 and 60 years. The progression of rounded shoulders was prevented in those performed these extension exercises three times a week for one year. 
Like everything else I teach you, compliance is important.
Exercises which strengthen the extensor muscles of the spine can delay the progression of hyperkyphosis (rounded back).

 

Source: Ball et al. Department of Physical Therapy Education, School of Allied Health, University of Kansas Medical Center, Kansas, KS, USA.

 

 

 

 

Feel free to forward our newsletter to your friends, family and coworkers.  And please feel free to contact me with your questions, comments and suggestions. 
Please stay committed to your health, fitness and nutrition efforts.
 
Warm regards,
 
 

 

Dr. Jeffrey Tucker
 

 

Dr. Tucker is certified in using the Functional Movement Screen (FMS) & just returned from Danville, VA with the developers of the FMS. When you start a fitness plan, it’s vital to be prepared. Commitment isn’t measureable, but physical readiness is. The FMS evaluates whether your body is ready to take on a fitness plan, puts you on the road to genuine wellness, and tracks your progress along the way. Dr. Tucker will be happy to perform the FMS on you.
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Vitamin D Update From the Annual Congress of the European League Against Rheumatism

June 16-19, 2010 in Rome, Italy — vitamin D deficiency is a common feature in patients with a range of painful rheumatic and related autoimmune disorders. What is less clear, however, is the amount of vitamin D supplementation that would benefit these patients.

Here are highlights from three recent studies:

  1. Researchers in the UK assessed levels of vitamin D in patients with either inflammatory joint diseases (ie, rheumatoid arthritis, RA), osteoporosis, or unexplained muscle pain (ie, myalgia) — 30 subjects in each group — compared with a control group of 90 patients with chronic back pain [Kelly et al. 2010]. Within all 180 patients (two-thirds female) the median vitamin D level was 15 ng/mL and 58% were below the normal range (defined as 20-58 ng/mL by these authors). The median vitamin D level in control patients (with back pain) was 20 ng/mL compared with statistically significant lower medians of 14 ng/mL in the RA group, 12 ng/mL in the osteoporosis group, and 12 ng/mL in the myalgia group. The authors expressed surprise that vitamin D deficiencies also were evident in persons with diffuse muscle pain but suggested that patients in all groups would benefit from vitamin D supplementation. Note: Why patients with back pain were chosen as a control group is unclear, as other research has already found such patients to be vitamin D insufficient (ie, <30 ng/mL) overall.
  2. A second study, conducted by Italian researchers, focused on 1,191 patients (85% female) with rheumatoid arthritis (RA) to determine a correlation between vitamin D deficiency and several clinical measures of disease activity [Idolazzi et al. 2010]. They found that levels of 25(OH)D were deficient (<20 ng/mL) in 52% of the patients not taking a vitamin D supplement and in one third of those taking supplements (?800 IU/day). In non-supplemented patients low levels of 25(OH)D significantly correlated with worse scores on 3 measures of disease activity: Health Assessment Questionnaire Disability Index, Mobility Activities of Daily Living Score, and Number of Swollen Joints Count. Significantly lower 25(OH)D levels were found in patients with active disease compared with those in disease remission and in those who were not responding to treatment compared with patients with a good response. Therefore, vitamin D sufficiency appears to be directly related to the course of rheumatoid arthritis and response to treatment; however, the authors conclude that further research is needed to assess the benefits of vitamin D supplementation in these patients.
  3. Another reported study from Italian researchers evaluated the impact of vitamin D supplementation in patients with either inflammatory autoimmune disease (IAD; rheumatoid arthritis, spondyloarthritis, or connective tissue diseases; n=43) and noninflammatory autoimmune disease (NIAD; osteoarthritis or osteoporosis; n=57) [Sainaghi et al. 2010]. Mean 25(OH)D levels between the two groups at outset were equivalently deficient — 12.6±7.5 ng/mL IAD group, 13.1±8.8 ng/mL NIAD group. Following daily supplementation with 800 to 1000 IU of vitamin D3 for 6 months, only 29% of all patients reached 25(OH)D levels ?30 ng/mL considered to be sufficient and there were no significant differences observed between the IAD and NIAD groups. The authors conclude that, while the amount of supplementation was not adequate to normalize 25(OH)D levels in their patients the response to vitamin D (or lack thereof) did not appear to be influenced by the presence of an inflammatory autoimmune condition.

COMMENTARY: A separate presentation at EULAR 2010, based on a large multinational survey of women with RA, reported that among the 75% who were taking analgesic medications more than 7 in 10 (72%) still experienced daily pain [Strand et al. 2010]. Two-thirds of the respondents said that they constantly look for new ideas to address pain. Therefore, the studies above are of great importance because they demonstrate that painful inflammatory and noninflammatory rheumatologic or bone conditions are generally accompanied by vitamin D deficiencies. Based on prior research, it is not surprising that daily supplementation of 800 to 1000 IU of vitamin D3 was inadequate to significantly raise 25(OH)D to more normal levels. It is disappointing that none of the 3 research teams proceeded to the next step of testing more ample vitamin D supplementation and assessing outcomes on pain relief and/or disease moderation.

REFERENCES: 
Idolazzi L, Bagnato G, Bianchi G, et al. Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants, and associations with disease activity. A cross-sectional study. Ann Rheum Dis. 2010;69(Suppl 3):516. Abstract SAT0093.
Kelly C, Scott K, Bell G, et al. Vitamin D levels in a spectrum of rheumatic disease. Ann Rheum Dis. 2010;69(Suppl 3:481. Abstract FRI0509.
Sainaghi PP, Bellan M, Carda S, et al. Response to vitamin D supplementation in inflammatory autoimmune diseases: a retrospective study. Ann Rheum Dis. 2010;69(Suppl 3):652. Abstract SAT0506.
Strand V, Emery P, Fleming S, Coke E. The impact of rheumatoid arthritis on women: focus on pain, productivity, and relationships. Ann Rheum Dis 2010;69(Suppl 3):748. Abstract OP0002-PARE.

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