All Posts tagged Nrf2

Oncoplex SGS – What you need to know about broccoli

– Found in broccoli (sprouts & seeds), Brussel sprouts & Kale.
Most potent transcription inducer of phase II & III detoxification & antioxidant enzymes via Nrf2.
– Increases production of antimicrobial peptides
– Bacteriocidal against H. pylori
– Anti-inflammatory: indirect inhibition of COX-2 enzymes
– Protective against airway inflammation (asthma, COPD, diesel exhaust)
– Decreases endothelial inflammation (diabetes, CVD); lowers blood pressure & LDL-cholesterol in lab animals.
– Protection against ARMD
– Neuroprotective against Parkinson’s, Alzheimer’s & Huntington’s Disease
– Resveratrol & sulphoraphane may be a viable approach for the treatment of glioma (Neurochemical research. 35(1):152-161, Jan 2010)
– May offer a possible treatment option for RA (Arthritis & Rheumatism. 62(1):159-170, 2010)
– Potential treatment for oxidant-induced airway disease (Riedl MA et al)
– Anti-inflammatory effects (Juurlink B, et al 2004)
– Protects against oxidative damage to retinal pigments in the eyes (age related macular degeneration) (Xiangqum, G et al 2004)
– A broccoli rich diet was found to perturb several pathways that lead to prostate cancer, including growth factor pathways, inflammation and insulin signaling (Traca M, et al 2008)
– Sulforaphane delayed the appearance of tumors (Zhang, Y et al 1994)

To get these benefits I recommend OncopPLEX ES. It provides 290-320 mmol/gram of Sulforaphane – the amount found in approximately 3.75 pounds of broccoli!!!


Dr. Tucker on Parkinson’s Disease

“Dear Dr. Tucker. My Mother is showing early signs of Parkinson’s Disease. Do you have any nutritional recommendations?”

RESPONSE: Based on research by Flint Beal, Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S189-94
A large body of evidence from postmortem brain tissue and genetic analysis in humans, as well as biochemical and pathological studies in animal models of neurodegeneration suggest that mitochondrial dysfunction is a key pathological mechanism in Parkinson’s Disease.

A promising approach for increasing antioxidant defenses is to increase the activity of pathways (Nrf2/ARE) which activates transcription of anti-inflammatory and antioxidant genes. A number of agents including sulforaphane, curcumin and triterpenoids have been shown to activate this pathway to produce neuroprotective effects.

This means the most effective foods or supplements include:
Sulforaphane (broccoli, brussle sprouts), curcumin & ginger, resveratrol, quercitin, alpha lipoic acid, rosemary, ginko biloba, garlic, cinnamon, green tea, milk thistle, organic coffee, wasabi.

I recommend the Mitochondrial Renewal Kit by XYMOGEN. Call me for more information about this product.