All Posts tagged metagenics

Triglycerides and heart disease link

Triglyerides are blood fats and are different from cholesterol. Cambridge University researchers looked at the role of triglycerides, which is produced in the liver and derived from foods such as meat and dairy products.

They did an analysis of 350,000 people from 101 previous studies and found those with higher levels of the blood fat were more likely to have heart disease.

The Lancet medical journal reported that the analysis centred on a specific gene which is known to influence the levels of triglycerides. Those with the variation in the gene which boosted triglyceride levels had an 18% greater risk of heart disease than those that did not.

The findings suggest the blood fat could be causing heart disease in some way. I’ve been saying for years that lowering triglyceride levels is more important than reducing cholesterol in reducing the risk of heart disease.

My advice is to make simple lifestyle changes; continue to eat a Paleo-Mediterranean diet; make the transition to a healthy, whole food diet; exercise; stop smoking; replace problem meals with a healthy protein shake (use UltraMeal Plus medical food from Metagenics). These are still the best ways to tackle your heart disease risk.

Most places you look these days are saying the TG/HDL ratio is the most important test of blood lipids, and should be under 2.0, or preferably under 1.0. Beyond that there is CRP, and a bunch of different, more expensive tests: http://www.bhlinc.com/clin_test.php http://www.atherotech.com/ http://www.atherotech.com/content/files/pdfs/vap_report_sample.pdf http://www.your-story.org/spectracell-laboratories-now-offers-hs-omega-3-indexr-161378/ http://www.spectracell.com/lpp

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Erectile Dysfunction

Erectile dysfunction is often a problem with circulation. Because it is an early indicator of problems with blood flow, the presence of erectile dysfunction may forewarn future cardiac problems.
Various herbs and nutrients have been studied. The Asian Journal of Andrology (2007; 9(2): 241-4) studied the effect of
Korean red ginseng in a double-blind, placebo-controlled study involving 60 subjects with erectile dysfunction. At the
end of the 12 week study, the group receiving 1000 mg of Korean Red Ginseng 3x per day had improvement of symptoms according to the five item version of the International Index of
Erectile Function (IIEF-5).

If ED is a concern for you, please feel free to discuss nutritional recommendations with me.

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BP Drops when Sugary Drinks Are Reduced

Cutting down on sugar-sweetened soft drinks was associated with a drop in blood pressure, researchers found. In a cohort of U.S. adults, those who reduced daily intake of the beverages saw a significant drop in both systolic and diastolic blood pressure.

full story http://www.medpagetoday.com/Cardiology/Hypertension/tb/20264

Many clients with High Blood Pressure are helped by eating a low-glycemic-index dietary food plan and exercise program while incorporating medical foods and nutritional supplements. A low glycemic diet is more effective than a low fat diet in treating obesity, insulin resistance, dyslipidemia, cardiovascular disease and type-2 diabetes.

The specific medical food I use is called UltraMeal® Plus 360 — 2 scoops twice daily
UltraMeal Plus 360 is a medical food formulated to provide specialized, multi-mechanistic
nutritional support for patients with metabolic syndrome and cardiovascular disease by supplying a combination of acacia extract, reduced iso-alpha acids (RIAA), plant sterols, and heart-healthy soy protein and isoflavones.

EPA-DHA Extra Strength® — 2 to 4 softgels twice daily. This is a concentrated and stabilized purity-certified, Omega-3 Fatty Acids

Nano Cell Q10— 1-2 tablespoons daily. Nano Cell Q10 is all natural coenzyme Q10 (CoQ10) manufactured to achieve exquisite quality, purity, and bioavailability. COQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. Deficiency is also implicated in increased incidence of cataracts, neoplasia, peripheral neuropathies, and some psychiatric disturbances.
ORDER these products by clicking on the Metagenics link

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Anti-inflammatory Diet

Regarding the Anti-inflammatory Diet: The whole point of the avoid list is to remove as much of the inflammatory foods and commonly allergenic foods to give the body a much needed rest and hopefully begin to rejuvenate. This is similar to an allergy elimination technique. For example, you know that wheat & dairy products are everywhere and one of the most allergic foods. These foods need to be eliminated first.

I have my patients follow the anti-inflammatory diet for a month and then add 1 food every few days. If eggs ( I also know they are a perfect protein food) are what you miss the most… make it the first thing to try. Patients find this sooo easy to do themselves.

I want my clients to feel responsible and enpowered to take charge of their own health using nutrition. Each day I hear new clients come in and share with me their disappointing stories of things they have already tried. After they have been on my anti-inflammatory diet program for a month (sometimes sooner), they come to find out they had an exaggerated immune reaction (IGG). Clients get the message quickly without any nagging from me. Please don’t think I’m going to be upset with you for not following the diet to a tee. I love watching patients teach themselves their own lessens.

This is an example of one of the product protocols I use to help ‘miracles’ occur in my patients.

Choice 1: Ultraclear/Advaclear 28 day from Metagenics. This is a great maximum bang for the detoxing buck.

Choice 2: Xymogen OptiCleanse GHI, Mitochondrial Kit 28 day cleanse. Both have simple directions.

I keep track of patients progress using the body composition analysis. I personally evaluate and work with each patient to ensure weight loss progress.

Chronic pain patients can have slower pogress….sometimes several years and patience is the hardest thing to do. I look for the slow and steady slope with my chronic pain patients.

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Long-Term Bisphosphonate Use Linked to Abnormal Bone Formation

An unusual type of bone fracture has been reported in women who have taken bisphosphonates for osteopenia and osteoporosis for more than 4 years, according to 2 studies reported at the American Association of Orthopaedic Surgeons 2010 Annual Meeting.

Joseph Lane, MD, chief of the Metabolic Bone Service at the Hospital for Special Surgery and professor of orthopedic surgery at Weill Cornell Medical College in New York City said concern is mounting that long-term use of these drugs might adversely affect bone quality.

Osteoporosis, a loss of bone mineral density that can occur as we age is a real concern to avoid because 1 in 5 patients who have a hip fracture die within 1 year.

Bisphosphonates have been shown to prevent the rapid loss of bone that occurs during the first years of menopause and to reduce the incidence of fracture in postmenopausal women.

However, there have been reports of “peculiar” fractures — that is, low-energy femur fractures that are seen in patients who have been on long-term bisphosphonate treatment. The first report was published in 2005 in a “semi-obscure” journal, Dr. Lane told Medscape Orthopaedics.

In a second unrelated study, Melvin P. Rosenwasser, MD, Robert E. Carroll Professor of Hand Surgery at Columbia University in New York City, and colleagues evaluated the bone structure of 112 postmenopausal women with primary osteoporosis, 62 of whom had been taking bisphosphonates for at least 4 years, and 50 control subjects who were taking only calcium and vitamin D supplements.

They found that bisphosphonate use improved structural integrity early in the course of treatment, but that these gains were diminished as treatment extended beyond 4 years.

“It seems as if there is a plateau of benefit at 4 or 5 years and, after that, the benefit is negated. In the early treatment period, patients using bisphosphonates experienced improvements in all parameters, including decreased buckling ratio and increased cross-sectional area,” he said in an interview with Medscape Orthopaedics. “But after 4 years of use, these trends reversed.”

Women (and men), If you have been on these drugs for 4 years, consider taking a break and use a natural supplement called Ostera from Metagenics instead.

American Association of Orthopaedic Surgeons (AAOS) 2010 Annual Meeting: Abstract 241, presented March 10, 2010; Abstract 339, presented March 11, 2010.

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HEALTHY AGING:

Every time your cells divide, a small portion of your DNA is lost. This is the section at the end of the chromosome, called the telomere. As you age, the telomere gets shorter and shorter. Finally, it disappears and the cell stops dividing and dies. Telomeres serve as a disposable buffer to protect chromosomes.
Physical aging occurs as more and more cells reach the end of their telomeres and die. As the process accelerates, your muscles get weaker, wrinkles appear and eyesight fades. Eventually the organs begin to fail and death occurs. Such is the nature of life.

Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
JAMA, 2010;303:250-257
– Researchers measured telomere length in leukocyes of 608 people with stable heart disease at the beginning of the stydy and again five years later.
– People who had the lowest blood levels of two key omega-3 fats, eicosapentaenoic acid (EPA) and docosahexenoic acid (DHA), experienced the most rapid rate of telomere shortening during the study. In contrast, those with the highest blood levels of EPA and DHA had the slowest rate of telomere shortening.

I recommend EPA-DHA 720 capsules by Metagenics. Order at clinking on the Metagenics link.

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High Blood Pressure Supplements

What YOU Can Do To Bring Your Blood Pressure Down
I do think regular Chiropractic Adjustments helps – this maintains vital nerve flow to the cardiovascular system; reduces mechanical stress to the nervous system; enhances all nutritional and dietary suggestions by allowing for optimal assimilation.

Lose 5-10 pounds because excess weight can often lead to increased blood pressure.

Give up “empty” calories like sugar, white bread, cake, cookies, pie, hard alcohol.

Try eating more fish, lean meat, vegetables, use butter, and eggs are OK.

Avoid corn and corn syrup (liquid corn oil, fructose corn syrup, etc).

Cut Down on Salt. Try to decrease the salt you add while cooking and not add any salt at the table. Avoid salt-loaded foods, such as chips, crackers, and canned foods high in sodium. Instead of salt, try cooking with other flavorings such as lemon juice, mint, mustard, herbs, curry, etc. Use your imagination!

Get More Exercise. Walk up and down stairs rather than taking the elevator. Walk the few blocks to the store rather than hopping in the car, etc. Try to be physically active every day, and be more intense about it.

Control Your Caffeine Intake – Coffee, tea, colas, and analgesics contain caffeine which can elevate blood pressure. A cup or two of coffee is not harmful, it contains lots of antioxidants.

Increase Consumption of Calcium, Garlic, Magnesium, Potassium-Rich Foods. Studies show that calcium, magnesium, garlic, and potassium may be more helpful in lowering blood pressure than salt restriction.

Increase Omega-3 Fatty Acids. Studies indicate that oils in fish may help lower blood pressure.

High blood pressure is a dangerous disease. If not brought under control, it can lead to strokes and heart attacks.

Here is a list of the supplements I recommend: You can order these from my website @ www.DrJeffreyTucker.com and link to Metagenics. They will mail these to you.

Wellness Essentials for Men/women formula — 2 packets daily

Vasotensin — 2 tablets twice daily with food. Vasotensin provides active peptides from bonito fish to help prevent the formation of angiotensin II, a potent vasoconstrictor, through their interaction with angiotensin converting enzyme (ACE). This activity supports healthy vascular function for optimal blood flow and healthy blood pressure levels.

NanaoCellQ — 1 teasspoon 1-2 times daily with meals. Highly Absorbable Coenzyme Q10 with Natural Vitamin E. Studies show that CoQ10 deficiency is present in 39% of people with hypertension. CoQ10 lowers blood pressure by lowering cholesterol levels and stabilizing the vascular membrane via its antioxidant properties.

Cardiogenics Intensive Care — 1-2 tablets 2 times daily between meals with juice. Nutritional support for healthy circulation and cardiac function. Calcium has been shown in studies to not only lower blood pressure, but also to help to prevent it. Some scientists have stated that calcium counteracts the effects that sodium has on blood pressure. Magnesium is another valuable mineral for controlling hypertension. Numerous studies show that magnesium has a positive effect on hypertension. It works by relaxing and smoothing the muscle of blood vessels and also plays a role in cell membrane permeability to sodium and calcium. Potassium is perhaps the best-known natural remedy for lowering blood pressure. One study published in the Journal of the American Medical Association found that low potassium levels contribute to the development of hypertension.

ActiFolate — 6-12 tablets daily with food. Actifolate is comprehensive folate nutrition in the active forms. Several studies have demonstrated that high-dose folic acid acutely lowers blood pressure and enhances coronary vasodilator function in patients with coronary artery disease.

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Osteoarthritis supplement program

I had a question from a Doctor about what nutritional recommendations I use for patients with Osteoarthritis. Here is my response.

Make sure they are consistent for at least 3 months on an Anti-inflammatory diet. Depending on the client I use either the Mediterranean Diet or Paleo Diet.

The following are supplements from my Metagenics site (www.meta-ehealth.com/site/office/index.jsp) that I recommend:
If it is a light to moderate case:
Kaprex — 1-2 softgel twice daily
Non-responders by day 5, move to 6 softgels daily
Time to benefit: 2 to 10 days.
Kaprex is an herbal supplement that provides natural joint relief that is easy on the gastrointestinal (GI) tract. It works by interfering with signals in the body that initiate the production of damaging compounds that cause minor pain and negatively impact cartilage and other joint tissues.
Chondro-Relief Intensive Care – 2-3 capsules twice daily
Chondro-Relief Intensive Care supports healthy joint function with Glucosamine HCI, Chondroitin Sulfate, Methyl-Sulfonyl-Methane (MSM), P. Canaliculus, Hyaluronic Acid, and Avocado/Soybean Unsaponifiables (ASU) in addition to other antioxidants that support healthy connective tissue.
EPA-DHA 6:1 Enteric Coated — 2 softgels three times daily. Omega 3 fatty acids are important for patients with chronic inflammatory conditions.
D3 5,000 — 1 tablet two times daily. Get there blood level checked & then dose up or down.

If it is a moderate to severe case:
UltraInflamX Plus 360 — 2 scoops twice daily. They make a shake in the morning & afternoon. It is a Medical food for inflammation and biotransformation.
Chondro-Relief Intensive Care – 2-4 capsules twice daily
EPA-DHA 6:1 Enteric Coated — 2 softgels three times daily. Omega 3 fatty acids providing a ratio appropriate for patients with chronic inflammatory conditions.
D3 5,000 — 1 tablet three times daily.

I have clients use Capsaicin cream and rub it on the involved area at least four times per day.

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Benign Prostate Hyperplasia (BPH)

By the time you are 60 years old — if you’re a man — there’s a fifty-fifty chance that you’ll be suffering from an enlarged prostate. If you live long enough, your chances climb to 90%.

An enlarged prostate — a condition called benign prostate hyperplasia (BPH), is a non-cancerous swelling of the prostate. As your prostate begins to swell, you’ll typically feel the urge to make more frequent trips to the bathroom, your urine stream could be weak, and you’ll have a hard time finishing, you’ll probable dribble more than usual.

An enlarged prostate can also interfere with your sex life and your overall quality of life. Often an enlarged prostate is a symptom of a hormone imbalance in part due to testosterone and estrogen imbalances. A process called aromatization causes testosterone to be converted to estrogen, triggering both male breast development and/or prostate problems. Most doctors take a ‘watch-and-wait’ approach to an enlarged prostate. They figure if it doesn’t grow too fast and the symptoms don’t become too severe, then it’s something you can live with. If the symptoms get worse and become unmanageable, then the next option they recommend is surgery.

This is not the approach I recommend for my clients. There are many intelligent options and steps to try prior to recommending surgery. In fact, you can begin treating your enlarged prostate right away. Many of the same steps you take now for an enlarged prostate can also protect you from prostate cancer in the future — an unrelated condition. Natural approaches can be successful in relieving a lot of the symptoms that come with an enlarged prostate.
Caring for an Enlarged Prostate…

How to Slow Its Growth and Keep it From Becoming a BIG Problem

Most doctors chalk up an enlarged prostate to a natural part of the aging process. And that’s why they feel comfortable taking a hands-off approach until things get real bad!
This pro-active strategy is part of a therapeutic lifestyle change that improves the quality of your life and has the added bonus of cutting your risks of cancer. So, just how do you keep your prostate from growing out-of-control?

I emphasize a proper diet as a major to help prostate health. This involves a low carbohydrate diet. It’s also important that you be physically active. Daily physical activity helps. Research shows that men who get the most exercise reduce their risks of an enlarged prostate by 40%. Increasing your metabolism and preventing muscle wasting (especially of type II muscle fiber) by strength training is very helpful. Doing only cardio aerobics won’t help muscle from wasting, in fact it may add to it. Resistance exercise is the key.

The way to stop/reverse, or outright prevent poor quality testosterone build up, is by doing resistance training with bodyweight exercise, free weights, kettlebells, bands, or cables – I do not recommend weight machines because these do not resemble real life movements. Weight machines limit motion and enhance loss of flexibility. Where in real life are you sitting down and pushing weights other than in a gym? You might call the combination of diet and resistance training Prostate Fitness.

Most people don’t want to do or stay committed to the fitness portion. We’ve been brainwashed into using food as medicine, as a substitute for pills and potions, and that alone will do it for us. Don’t be lazy! Put a demand on your endocrine system so that testosterone is being used. Thirty minutes of high intensity weight training four-six times a week will restore your manliness.

Once you start eating right and taking care of your embodiment, many ailments/problems start to disappear – and instead of a swollen prostate, a new healthy guy comes to life.

The diet must include cruciferous vegetables like broccoli, cauliflower, or cabbage five to six times a week. Snacks that are high in zinc and magnesium are also beneficial to your prostate.

Higher levels of estradiol promote prostate enlargement and getting that under control reduces the problem. For some men, the problem is that testosterone gets converted to estradiol, especially if testosterone replacement uses patches or creams – less so with injections. The life extension foundation, while not mentioning prostate issues specifically, notes after a review of almost all the literature on estradiol that estradiol is best in men when it is within the 20-30 ng/ml range. Lower levels and higher levels than 20-30 ng/ml leads to a greater incidence of stroke, heart problems, bone thinning and other issues. The lab reference range goes from 0 to 50 or so.

Additionally, having high or low estradiol leads to Erectile Dysfunction (ED), depression, anxiety, lethargy, low motivation and a whole host of other problems that one’s doctor is prone to prescribe a wide range of drugs instead of testosterone replacement. Most often men require supplements to prevent Testosterone from converting to estradiol.

Some Physicians hold that DHT (5-alpha diHydroxyTestosterone) is the culprit of prostate health. Areas of the body rich in hair follicles are also rich in 5-alpha reductase, the enzyme producing DHT. That conversion can be thwarted by means of half doses of OTC progesterone (found in the menopause section of natural food stores).
Supplements
Supplements I recommend can be ordered on my website by clicking onto the Metagenics website.

Testralin is designed and intended for daily, ongoing support of the prostate gland and to balance hormones in aging males (40 years and older). In terms of mechanism of action:

– The vitamins and minerals in the formula (for example Vitamin B6, B12, and folic acid) support liver enzymes involved in hormone detoxification.
– The isoflavones and lignans support sex hormone binding globulin (SHBG) production and sensitivity.
– Isoflavones also have an inhibitory effect on 5-alpha reductase, the enzyme in the prostate that converts testosterone to 5-alpha dihydrotestosterone, the main prostatic androgen. Furthermore, isoflavones are also known to inhibit aromatase activity, the enzyme in adipose tissue that converts androgens to estrogens. Lastly, according to the article attached, since prostate cancers and BPH specimens can express estrogen receptors, their growth may also be inhibited by the antiestrogenic effects of isoflavones.
– Turmeric serves as an anti-inflammatory and the green tea catechins are powerful antioxidants that protect tissues from oxidative stress.

Tribulus Synergy (aka puncture vine) has traditionally been used (literally for more than 1000 years) as an aphrodisiac for males. It has recently been used as a performance enhancer by some former Eastern block countries. While the mechanism is not really known, it is felt that Tribulus Synergy decreases testosterone clearance as opposed to directly stimulating its production.

Ashwagandha, also referred to as “Indian Ginseng,” has also been traditionally used as a “tonic” for men. Finally, cowage/mucuna contains natural L-dopa, a side-effect of which is spontaneous erection.

Thus, the rationale for using Tribulus Synergy is more philosophical and in line with the traditional use of these herbs contained in the formula. While Tribulus has very controversial documentation in western literature, it is one of the oldest herbs in Traditional Chinese Medicine and is well respected in that circle.

1. Tribulus.
“… In castrated rats, increases in [testosterone] levels by 51% and 25% were observed with [testosterone] and [tribulus] extract respectively that were statistically significant. [Tribulus] increases some of the sex hormones, possibly due to the presence of protodioscin in the extract. [Tribulus] may be useful in mild to moderate cases of ED…” Phytomedicine. 2008 Jan;15(1-2):44-54. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction–an evaluation using primates, rabbit and rat. Gauthaman et al.
2. Ashwagandha.
“…Withania somnifera, popularly known as Ashwagandha is widely considered as the Indian ginseng. In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity…” Prog Neuropsychopharmacol Biol Psychiatry. 2007 Sep 21 Withania somnifera: An Indian ginseng. Kulkarni et al.
3. Mucuna.
“…Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson’s disease…” Phytother Res. 2004 Sep;18(9):706-12. Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Manyam et al.

“…From animal research, there is ample evidence for a facilitating effect of dopamine on sexual behavior…These results support the view that dopamine is involved in the energetic aspects of appetitive sexual behavior in men…” Neuropsychopharmacology. 2005 Jan;30(1):173-83. Effect of a single dose of levodopa on sexual response in men and women. Both et al.

Other supplements often recommended are Nettle root (not leaf). This is a very good supplement to take if you’re suffering from benign prostate enlargement. Nettle inhibits the Aromatase and 5-Alpha Reductase enzymes that cause enlargement of the prostate, and it inhibits the binding of DHT to the prostate cells. Just don’t overdo it…take too much, or take it too often, and you’ll experience a reduction in your testosterone levels.

Vitamin D3 is particularly important for prostate health and the higher ones blood serum levels, the lower the chance of prostate problems including cancer.

I hope this helps!

Dr. Jeffrey Tucker

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