All Posts tagged Hypertension

Vitamin D update

This meta-analysis supports a strong connection between low vitamin D and hypertension.

At the 2013 European Human Genetics conference in Paris, France, researchers discussed the largest study to ever examine a link between hypertension and vitamin D deficiency.  Dr. Vimal Karani Santhanakrishnan of the University College London said the results demonstrated “a significant link; for every 10% increase in 25(OH)D concentrations, there was a 8.1% decrease in the risk of developing hypertension.” The conclusion: “Our study strongly suggests that some cases of cardiovascular disease could be prevented through vitamin D supplements or food fortification.”

Santhanakrishnan, V. K. (2013, June). Genetic research clarifies link between hypertension and Vitamin D deficiency. Presented at 2013 European Human Genetics Conference, Paris, France.  https://www.eshg.org/474.0.html

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Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.

Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, Strauman TA, Sherwood A.  Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.  Hypertension. 2010 Jun;55(6):1331-8

“High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction. Although aerobic exercise and dietary modifications have been shown to reduce blood pressure, no randomized trials have examined the effects of aerobic exercise combined with dietary modification on neurocognitive functioning in individuals with high blood pressure (ie, prehypertension and stage 1 hypertension). As part of a larger investigation, 124 participants with elevated blood pressure (systolic blood pressure 130 to 159 mm Hg or diastolic blood pressure 85 to 99 mm Hg) who were sedentary and overweight or obese (body mass index: 25 to 40 kg/m(2)) were randomized to the Dietary Approaches to Stop Hypertension (DASH) diet alone, DASH combined with a behavioral weight management program including exercise and caloric restriction, or a usual diet control group. Participants completed a battery of neurocognitive tests of executive function-memory-learning and psychomotor speed at baseline and again after the 4-month intervention. Participants on the DASH diet combined with a behavioral weight management program exhibited greater improvements in executive function-memory-learning (Cohen’s D=0.562; P=0.008) and psychomotor speed (Cohen’s D=0.480; P=0.023), and DASH diet alone participants exhibited better psychomotor speed (Cohen’s D=0.440; P=0.036) compared with the usual diet control. Neurocognitive improvements appeared to be mediated by increased aerobic fitness and weight loss. Also, participants with greater intima-medial thickness and higher systolic blood pressure showed greater improvements in executive function-memory-learning in the group on the DASH diet combined with a behavioral weight management program. In conclusion, combining aerobic exercise with the DASH diet and caloric restriction improves neurocognitive function among sedentary and overweight/obese individuals with prehypertension and hypertension.

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Capsaicin & Hypertension

Studies have suggested a role for plant compounds in lowering cardiovascular risks including hypertension (high blood pressure). Zhiming Zhu, from the Third Military Medical University (China), and colleagues completed a study examining the effects of long-term treatment with capsaicin on high blood pressure in a laboratory animal model.  The team found that long-term dietary consumption of capsaicin, the active compound in chili peppers that lends the vegetable’s spiciness, reduced blood pressure in genetically hypertensive rats. The effects were resultant from a chronic activation of the transient receptor potential vanilloid 1 (TRPV1) channel found in the lining of blood vessels, whereby activation of the channel leads to an increase in production of nitric oxide, a gaseous molecule known to protect blood vessels against inflammation and dysfunction.  Writing that: “We conclude that TRPV1 activation by dietary capsaicin improves endothelial function.”  The researchers submit that: [This mechanism] “may represent a promising target for therapeutic intervention of hypertension.”

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