All Posts tagged Hypertension

Nitric Oxide: Hypertension. Erectile Dysfunction

Safe, effective and natural approaches for reducing blood pressure and men’s health.

Nitric oxide or NO, is an important signaling molecule in the human body.

One of the best ways to increase NO is by using Shock Wave Therapy and eating sources of nitrates such as beetroot, arugula and spinach.1 After eating these foods, the dietary nitrate molecules are metabolized by oral bacteria into nitrites which are then endogenously transformed into the cardioprotective NO molecule.2-3

NO plays a critical role in cardiovascular health and men’s health. For example, low levels of NO in the body can lead to various pathologies, most notably endothelial dysfunction which contributes to hypertension and atherosclerosis; low NO has also been found to play a role in diabetes, hypercholesterolemia and Erectile Dysfunction.1

Healthy levels of NO in the body support vascular tone, healthy blood flow, leukocyte adhesion, and platelet aggregation.Consuming food-based nitrates on a routine basis, and getting treatment with Shock Wave is a logical next step for those desiring to prevent or treat NO deficiency-related disease processes. The science backs it up.

A study published in Nutrition Reviews looked at 23 studies that measured blood pressure, endothelial function, arterial stiffness, platelet aggregation, and/or blood lipid outcomes in response to oral inorganic nitrate/nitrite intake.4 The analyses demonstrated that inorganic nitrate intake significantly reduced resting blood pressure, improved endothelial function (measured as flow-mediated dilatation), arterial stiffness, and platelet aggregation.4

Put it all together – Shock Wave therapy, beets, beetroot juice, quinoa, spinach, and lamb’s quarters (AKA wild spinach) to increase NO.

One of the beetroot studies found that daily supplementation with dietary nitrate from beetroot juice was associated with a reduction in blood pressure: systolic ?7.7-8.1mmHg; diastolic ?2.4-5.2mmHg.6Additionally, endothelial function improved by approximately 20% and there was a reduction in arterial stiffness by 0.59m/s.6

Overall reduction in systolic and diastolic blood pressure of 3.55 mmHg and 1.32 mmHg, respectively, and these reductions were significantly greater in the beetroot juice supplemented groups vs. control groups.7 This same publication also noted greater improvements in blood pressure with higher (500 mL/day) vs. lower (70-140 mL/day) beetroot juice doses or with longer periods of consumption (?2 weeks vs. <2 weeks).7

So, eat your vegetables and do Shock Wave for ED and/or hypertension.

Citations

  1. Luiking YC et al. Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care. 2010; 13(1): 97–104.
  2. Hobbs DA et al. Blood pressure lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr. 2012;108(11):2066-74.
  3. Khatri J et al. It is rocket science – why dietary nitrate is hard to “beet”! Part I: twists and turns in the realization of the nitrate-nitrite-NO pathway. Br J Clin Pharmacol. 2017;83(1):129–139.
  4. Jackson JK et al. The role of inorganic nitrate and nitrite in cardiovascular disease risk factors: a systematic review and meta-analysis of human evidence. Nutr Rev. 2018;76(5):348-371.
  5. Encyclopedia Brittanica. Amaranthaceae. https://www.britannica.com/plant/Amaranthaceae. Accessed July 26, 2018.
  6. Vikas K et al. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 2015;65(2):320–327.
  7. Bahadoran Z et al. The nitrate-independent blood pressure-lowering effect of beetroot juice: a systematic review and meta-analysis. Adv Nutr. 2017;8(6):830-838.

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Vitamin D update

This meta-analysis supports a strong connection between low vitamin D and hypertension.

At the 2013 European Human Genetics conference in Paris, France, researchers discussed the largest study to ever examine a link between hypertension and vitamin D deficiency.  Dr. Vimal Karani Santhanakrishnan of the University College London said the results demonstrated “a significant link; for every 10% increase in 25(OH)D concentrations, there was a 8.1% decrease in the risk of developing hypertension.” The conclusion: “Our study strongly suggests that some cases of cardiovascular disease could be prevented through vitamin D supplements or food fortification.”

Santhanakrishnan, V. K. (2013, June). Genetic research clarifies link between hypertension and Vitamin D deficiency. Presented at 2013 European Human Genetics Conference, Paris, France.  https://www.eshg.org/474.0.html

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Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.

Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, Strauman TA, Sherwood A.  Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.  Hypertension. 2010 Jun;55(6):1331-8

“High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction. Although aerobic exercise and dietary modifications have been shown to reduce blood pressure, no randomized trials have examined the effects of aerobic exercise combined with dietary modification on neurocognitive functioning in individuals with high blood pressure (ie, prehypertension and stage 1 hypertension). As part of a larger investigation, 124 participants with elevated blood pressure (systolic blood pressure 130 to 159 mm Hg or diastolic blood pressure 85 to 99 mm Hg) who were sedentary and overweight or obese (body mass index: 25 to 40 kg/m(2)) were randomized to the Dietary Approaches to Stop Hypertension (DASH) diet alone, DASH combined with a behavioral weight management program including exercise and caloric restriction, or a usual diet control group. Participants completed a battery of neurocognitive tests of executive function-memory-learning and psychomotor speed at baseline and again after the 4-month intervention. Participants on the DASH diet combined with a behavioral weight management program exhibited greater improvements in executive function-memory-learning (Cohen’s D=0.562; P=0.008) and psychomotor speed (Cohen’s D=0.480; P=0.023), and DASH diet alone participants exhibited better psychomotor speed (Cohen’s D=0.440; P=0.036) compared with the usual diet control. Neurocognitive improvements appeared to be mediated by increased aerobic fitness and weight loss. Also, participants with greater intima-medial thickness and higher systolic blood pressure showed greater improvements in executive function-memory-learning in the group on the DASH diet combined with a behavioral weight management program. In conclusion, combining aerobic exercise with the DASH diet and caloric restriction improves neurocognitive function among sedentary and overweight/obese individuals with prehypertension and hypertension.

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Capsaicin & Hypertension

Studies have suggested a role for plant compounds in lowering cardiovascular risks including hypertension (high blood pressure). Zhiming Zhu, from the Third Military Medical University (China), and colleagues completed a study examining the effects of long-term treatment with capsaicin on high blood pressure in a laboratory animal model.  The team found that long-term dietary consumption of capsaicin, the active compound in chili peppers that lends the vegetable’s spiciness, reduced blood pressure in genetically hypertensive rats. The effects were resultant from a chronic activation of the transient receptor potential vanilloid 1 (TRPV1) channel found in the lining of blood vessels, whereby activation of the channel leads to an increase in production of nitric oxide, a gaseous molecule known to protect blood vessels against inflammation and dysfunction.  Writing that: “We conclude that TRPV1 activation by dietary capsaicin improves endothelial function.”  The researchers submit that: [This mechanism] “may represent a promising target for therapeutic intervention of hypertension.”

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