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Vitamin D Helps Parkinson’s Disease

High blood levels of vitamin D may reduce the risk of developing Parkinson’s disease by 67%, compared with low levels of the sunshine vitamin, says a new study from Finland.

Researchers from the National Institute for Health and Welfare in Helsinki analyzed data from 3,173 Finnish men and women aged between 50 and 79. Over an impressive 29 years of follow-up, the researchers documented 50 cases of Parkinson’s disease.

The study is reported to be the first longitudinal analysis of vitamin D status and the risk of Parkinson’s disease.

Writing in the Archives of Neurology, the authors note that the exact mechanism is unknown, but postulated that vitamin D may be exerting a benefit through antioxidant activities, regulation of calcium levels, detoxification, modulation of the immune system and enhanced conduction of electricity through neurons.

“Our results are in line with the hypothesis that low vitamin D status predicts the development of Parkinson[‘s] disease,” the researchers wrote. “Because of the small number of cases and the possibility of residual confounding, large cohort studies are needed. In intervention trials focusing on effects of vitamin D supplements, the incidence of Parkinson[‘s] disease merits follow up.”

In an accompanying editorial, Marian Leslie Evatt, MD, MS, from Emory University in Atlanta described the study as “the first promising human data to suggest that inadequate vitamin D status is associated with the risk of developing Parkinson’s disease.”

Evatt cautioned however that “further work is needed in both basic and clinical arenas to elucidate the exact role, mechanisms and optimum concentration of vitamin D in Parkinson’s disease.”

Previous studies have shown that the part of the brain affected most by Parkinson’s, the substantia nigra, contains high levels of the vitamin D receptor, which suggests vitamin D may be important for normal functions of these cells.

The study involved the measurement of vitamin D levels in over 3,000 people. The data showed that people with the lowest levels of vitamin D were three times more likely to develop Parkinson’s, compared to the group with the highest levels.

In the editorial, Evatt added that “it seems prudent to confirm the findings presented in this issue and investigate whether the apparent dose-response relationship observed in the current study maintains its slope, levels off or becomes negative with higher 25-hydroxyvitamin D concentrations.”

“In the interim, data from interventional studies of fractures and falls appear to justify optimizing vitamin D levels to greater than 30 to 40 nanograms per milliliter,” she concluded.

Archives of Neurology 57(7):808-811, 2010

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Oncoplex SGS – What you need to know about broccoli

Sulforaphane
– Found in broccoli (sprouts & seeds), Brussel sprouts & Kale.
Most potent transcription inducer of phase II & III detoxification & antioxidant enzymes via Nrf2.
– Increases production of antimicrobial peptides
– Bacteriocidal against H. pylori
– Anti-inflammatory: indirect inhibition of COX-2 enzymes
– Protective against airway inflammation (asthma, COPD, diesel exhaust)
– Decreases endothelial inflammation (diabetes, CVD); lowers blood pressure & LDL-cholesterol in lab animals.
– Protection against ARMD
– Neuroprotective against Parkinson’s, Alzheimer’s & Huntington’s Disease
– Resveratrol & sulphoraphane may be a viable approach for the treatment of glioma (Neurochemical research. 35(1):152-161, Jan 2010)
– May offer a possible treatment option for RA (Arthritis & Rheumatism. 62(1):159-170, 2010)
– Potential treatment for oxidant-induced airway disease (Riedl MA et al)
– Anti-inflammatory effects (Juurlink B, et al 2004)
– Protects against oxidative damage to retinal pigments in the eyes (age related macular degeneration) (Xiangqum, G et al 2004)
– A broccoli rich diet was found to perturb several pathways that lead to prostate cancer, including growth factor pathways, inflammation and insulin signaling (Traca M, et al 2008)
– Sulforaphane delayed the appearance of tumors (Zhang, Y et al 1994)

To get these benefits I recommend OncopPLEX ES. It provides 290-320 mmol/gram of Sulforaphane – the amount found in approximately 3.75 pounds of broccoli!!!

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