All Posts tagged CoQ10

CoQ10 and Lipitor?

By 21 Aug, 2012 Blog , ,

CoQ10: It’s great for the heart, great for energy, and a powerful antioxidant — and an excellent addition to a supplement program at a dose of at least 50-100 mg a day.
If a patient is on a statin medication for cholesterol (like Lipitor or Zocor) you must — repeat must — supplement with CoQ10. The statin drugs deplete it and your heart will suffer. If the MD doesn’t know this, or hasn’t told you this, change MD’s. Statin users should take a minimum of 200 mg daily in a supplement, and some doctors recommend up to 300 mg, especially if you have heart problems. Everyone else should be good with 100 mg per day.

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Co-enzyme Q10 before exercise

By 24 Nov, 2011 Daily Exercises, Fitness & Exercise, Nutrition , , ,

Co-enzyme Q10 – also known as ubiquinone – is a powerful antioxidant found in every cell of the body, where it has important functions within the mitochondria – the “powerhouses” of cells.  Javier Diaz-Castro, from the University of Granada (Spain), and colleagues studied elite runners participating in a 50-kilometer run across Europe’s highest road in the Sierra Nevada. Twenty athletes participated in the study, who were divided into two groups: one group received one 30 mg capsule of Q10 two days before the run, three 30 mg capsules the day before the run, and one capsule one hour prior to the run. The other group received placebo at the same time. Whereas the placebo group displayed a 100% increase in oxidative stress markers, only 37.5% of the Q10-supplemented runners experienced the same stresses. Suggesting that Q 10 countered the overexpression of certain pro-inflammatory compounds after exercise, the researchers conclude that: “Co Q10 supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.”

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Antioxidants update

By 05 Jun, 2011 Nutrition , , , , ,
Free radicals are believed to help many health problems and prevent heart disease, cancer and other disorders. Antioxidants are substances that protect cells against the effects of free radicals — molecules produced when the body breaks down food or is exposed to environmental toxins and radiation. I believe there are benefits in taking antioxidants especially in those with cardiovascular risks.

Vitamin C, vitamin E, coenzyme Q10 and selenium produce multiple positive effects on sugar and fat metabolism, blood pressure and arterial flexibility (which allows blood to move freely through the body).

Reuven Zimlichman and his research team at Wolfson Medical Center in Israel randomly divided 70 high blood pressure patients into two groups. One group was given antioxidants supplements and the other took placebo capsules for six months. Those taking the antioxidants received vitamin C (1000 mg/day), vitamin E (400 i.u/day), coenzyme Q10 (120 mg/day) and selenium (200 mcg/day).

Tests at the beginning of the trial, after three months, and again after six months documented that patients in the antioxidant group had marked improvements in their cardiovascular health. Cardiovascular profiles and cholesterol panels were healthier. The researchers concluded “antioxidant supplements have the potential to alleviate atherosclerotic damage..”

“Antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors. This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as significant decrease in blood pressure,” Dr. Zimlichman said in a statement to the media. “The findings of the present study justify investigating the overall clinical impact of antioxidant treatment in patients with multiple cardiovascular risk factors.”

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CoQ10

By 26 Apr, 2011 Blog, Healthy Aging, Nutrition ,

I take CoQ10 daily. Adding CoQ10 in therapeutic doses to some clients regimen seems to help the ‘turning point’. Lots of evidence supports its use for heart and/or circulation problems. CoQ10 has shown promise in the treatment of a variety of neurological diseases including Parkinson’s disease, Multiple Sclerosis, migraine headaches, and others. So what is this magic substance?

CoQ10, also known as Ubiquinone, so named because it is ubiquitous in our cells, is a fat soluble (meaning found in fat, absorbed in fat, and utilized in fat metabolism) “nutrient” that is a catalyst for the production of energy from the mitochondria. Mitochondria produce energy we need to carry out our lives. CoQ10 seems to be the prime catalyst or stimulant to this mitochondrial production of energy and probably its rate-limiting step. Therefore it affects all health processes because one cannot heal, white blood cells cannot migrate to the site of the infection or tumor, and circulation cannot flow properly without adequate energy being generated by our cells. This is the role of CoQ10.

CoQ10 is called an anti-oxidant. If you are on statin drugs, you need to take COQ10…period. Lipitor, Zocor, etc. deplete the body of its CoQ10 stores, probably because being a toxin, it shifts the energy needs of the body in the direction of detoxing the drug, leaving the patient exposed to fatigue, congestive heart failure, and a host of neurological illnesses.

I think at least 200 mg per day in circulatory disorders and cancer and up to 2400 mg per day in neurological illnesses is reasonable.

Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, Littarru GP, Doring F. Biomedical Research Institute, Otto-Heubner-Centre, Charite School of Medicine, Free University and Humboldt-University, D-13353 Berlin, Germany. Int J Biochem Cell Biol. 2005 Jun;37(6):1208-18. Epub 2005 Jan 19.

Abstract: Coenzyme Q10 is an essential cofactor in the electron transport chain and serves as an important antioxidant in both mitochondria and lipid membranes. These findings indicate a prominent role of CoQ10 as a potent gene regulator. The presently identified comprehensive list of genes regulated by CoQ10 may be used for further studies to identify the molecular mechanism of CoQ10 on gene expression. PMID: 15778085

Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up. Hart PE, Lodi R, Rajagopalan B, Bradley JL, Crilley JG, Turner C, Blamire AM, Manners D, Styles P, Schapira AH, Cooper JM. University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, England. Arch Neurol. 2005 Apr;62(4):621-6.

Abstract: This study is intended to evaluate the long-term efficacy of a combined antioxidant and mitochondrial enhancement therapy on the bioenergetics and clinical course of FRDA. Publication Types: Clinical Trial PMID: 15824263

Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, Pandey S. Department of Biochemistry and Chemistry, 277-1 Essex Hall, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4. Neurobiol Dis. 2005 Apr;18(3):618-27.

Abstract: Our study suggests that water-soluble Coenzyme Q10 acts by stabilizing the mitochondrial membrane when neuronal cells are subjected to oxidative stress. Therefore, Coenzyme Q10 has the potential to be used as a therapeutic intervention for neurodegenerative diseases. PMID: 15755687

Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Sandor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Headache and Pain Unit, Neurology Department, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland. Neurology. 2005 Feb 22;64(4):713-5

 Abstract: We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; CoQ10 is efficacious and well tolerated. PMID: 15728298

Bovine cartilage, coenzyme Q10, and wheat grass therapy for primary peritoneal cancer. Forgionne GA. University of Maryland, Baltimore County, Catonsville, MD 21250, USA. J Altern Complement Med. 2005 Feb;11(1):161-5.

 Abstract: The accepted postsurgical first-line therapy for primary peritoneal cancer has been a regime of chemotherapy. This paper reports the case of an 89-year-old female who refused chemotherapy but accepted a nutritional alternative. Results after more than 4 years of the nutritional regime have been encouraging with regards to objective and subjective measures. Publication Types: Case Reports PMID: 15750376

Integrated treatment approach improves cognitive function in demented and clinically depressed patients. Bragin V, Chemodanova M, Dzhafarova N, Bragin I, Czerniawski JL, Aliev G. Stress Relief and Memory Training Center, Brooklyn, New York, USA. Am J Alzheimers Dis Other Demen. 2005 Jan-Feb;20(1):21-6.

 Abstract: The purpose of this study was to evaluate the efficacy of an integrative treatment approach on cognitive performance. PMID: 15751450 [Coenzyme Q10: biochemistry, pathophysiology of its deficiency and potential benefit of an increased intake] [Article in French] Malchair P, Van Overmeire L, Boland A, Salmon E, Pierard L, Seutin V. Service de Pharmacologie et CNCM, Universite de Liege. Rev Med Liege. 2005 Jan;60(1):45-51.

Abstract: After a brief reminding of the synthesis and function of coenzyme Q10, this article tries to summarise the current state of knowledge about the consequences of its deficiency and about the potential benefits of an increased intake of this coenzyme. We then describe the arguments in favour of such an increase in cardiac diseases and in Parkinson’s disease. PMID: 15771317

Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10. McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S. Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada. Toxicol Appl Pharmacol. 2004 Nov 15;201(1):21-31.

 Abstract: Neuronal cell death induced by oxidative stress is correlated with numerous neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke. Pretreatment with CoQ10 was able to inhibit ROS generation from isolated mitochondria as well as the collapse of mitochondrial membrane potential. Our results indicate that water-soluble CoQ10 can prevent oxidative stress and neuronal damage induced by paraquat and therefore, can be used for the prevention and therapy of neurodegenerative diseases caused by environmental toxins. PMID: 15519605

Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Shults CW, Flint Beal M, Song D, Fontaine D. Department of Neurosciences, University of California, San Diego, La Jolla 92093-0662, USA. Exp Neurol. 2004 Aug;188(2):491-4.

 Abstract: The safety and tolerability of high dosages of coenzyme Q10 were studied in 17 patients with Parkinson’s disease (PD) in an open label study. Publication Types: Clinical Trial; Clinical Trial, Phase II PMID: 15246848 Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Berman M, Erman A, Ben-Gal T, Dvir D, Georghiou GP, Stamler A, Vered Y, Vidne BA, Aravot D. Department of Cardiothoracic Surgery, Heart-Lung Transplant Unit, Rabin Medical Center, Beilinson Campus, Potah Tikva, Israel. Clin Cardiol. 2004 May;27(5):295-9.

Abstract: The purpose of the present double-blind, placebo-controlled, randomized study was to assess the effect of CoQ10 on patients with end-stage heart failure and to determine if CoQ10 can improve the pharmacological bridge to heart transplantation. The administration of CoQ10 to heart transplant candidates led to a significant improvement in functional status, clinical symptoms, and quality of life. Publication Types: Clinical Trial, Randomized Controlled Trial PMID: 15188947

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CoQ10

By 03 Feb, 2011 Nutrition , ,

 Last Saturday night I was sitting in a restaurant enjoying dinner with Maddy, Maria & and my sister-in-law Sissy. Sissy started telling us that she’s been taking fish oils and CoQ10 (both of which I suggested she take a long time ago). She said with pleasure that “CoQ10 caused me to lose weight.” I sat and listened as she went on about how CoQ10 works. She was pretty right on about how it is “natural and we cannot survive without it and it creates energy which our cells use to exist.”

I piped in about how CoQ10 is especially good for the heart. It helps prevent congestive heart failure (CHF). If your heart fails to pump enough blood to meet your needs this leads to fluid congestion. That’s serious stuff! But I did have to tell her that I felt the fish oils probably did more for her weight loss than the CoQ10.

C0Q10 successfully treats:

  • heart disease
  • high blood pressure
  • high cholesterol

It’s not difficult to make CoQ10 a part of your daily diet. A great source of CoQ10 is organ meats from grass-fed animals. If you take CoQ10 in supplement form, I recommend CoQmax CF (50 mg a day) from Xymogen. You can order by calling 1-800-647-6100. Just let them know I referred you!

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How important is COQ10?

By 29 Oct, 2010 Healthy Aging, Nutrition , , , , , , , , , , ,

It’s very helpful for energy and the immune system

These benifits of taking Coenzyme Q10 – increased energy, improved metabolism, weight loss, cell protection, neuological health, and better cardiovascular health – are well established.

Most people over 50 have a hard time converting CoQ10 into its usable form. The lion’s share of the valuable CoQ10 enzyme disappears – making it impossible to give your cells the protection and nourishment they need.

Order CoQmax CF from XYMOGEN
 XYMOGEN

1-800-647-6100

Code TUC 500

Better absorption means you can get more CoQ10 in your system while actually taking fewer pills.

I use CoQmax CF by XYMOGEN – it’s in a stronger form – so it is much more easily absorbed.

The outer caplet is a soft gel encasing a precisely measured dosage of 50 mg – my daily recommended requirements – of liquid ubiquinol CoQ10.

The smooth outer caplet is easy to swallow. Once inside your body, the gel quickly dissolves, rapidly releasing liquid CoQ10. This highly water soluble liquid is rapidly – and fully – absorbed into your system.

CoQmax CF by XYMOGEN 1-800-647-6100 

 

 

CoQmax CF contains CoQ10 that helps increase energy … improve metabolic function, cell protection, better cardiovascular health and weight loss.

Heart health … according to the Journal of Cardiovascular Pharmacology, a number of clinical studies have found CoQ10 promotes cardiovascular health.

Blood sugar … an Australian study showed that patients who took CoQ10 were able to maintain blood sugar levels that are already within the normal range.

Vision … in a recent clinical trial, taking CoQ10 for a year helped them see more clearly.

Cognition … an animal study performed at Johns Hopkins University found that CoQ10 supplementation improves learning and memory.

Gum health … CoQ10 can improve gum and oral health.

Clear-headed comfort … in one study, more than 6 out of 10 patients treated with CoQ10 daily reported feeling more clear-headed comfort.

Oxidative stress … CoQmax CF is a powerful antioxidant, eliminating the free radicals that can cause damage to cell membranes and mitochondria.

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Top 7 Supplements for Men

By 10 Sep, 2010 Healthy Aging, Heart Health, Inflammation, Male issues, Nutrition , , , , , , , , , , , ,

Tribulus Fruit – a key herb used traditionally to support male libido and healthy sexual function.
Dr. Tucker’s pick: Tribulus Synergy by Metagenics. This provides Tribulus Fruit, Ashwagandha Root & Cowage Seed. This all-in-one herbal formula is used for vigor, vitality & positive mood.
 
CoQ-10  – can lower your blood pressure while boosting your levels of ecSOD, an enzyme thought to protect blood vessels from damage. CoQ-10 may also improve sperm quality. Japanese researchers found it can increase fat burning during exercise. This is an absolute must supplement if you are taking a statin drug (cholesterol lowering drug).

Dr. Tucker’s pick:  NanoCell-Q by Metagenics. This is a highly absorbable form of CoQ10. I also like the orange flavor. Natural sources include meat, fish, eggs, and broccoli.

 

Vitamin D – is a hormone that helps your bones absorb calcium. Vitamin D has been linked to reduced levels of depression, reduced risk of colorectal cancer, less chance of a heart attack, and supports the immune functions.

 

Dr. Tucker’s pick: Iso D3 by Metagenics. This delivers 2,000 IU of the active form of vitamin D in the body. Natural sources include sunshine and fortified milk.

 
EPA-DHA Omega 3 Fatty Acids – these are essential! Fish oil can reduce triglycerides, boost HDL cholesterol, lower blood pressure, reduce inflammation, supports healthy brain & nervous system function. Omega 3’s also support optimal joint function. Omega 3’s may lower your risk of colon and prostate cancers as well. I want everyone of my patients, male & female on this supplement! 
Dr. Tucker’s pick: OmegaPure 780 by XYMOGEN (call 1-800-647-6100 to order. Use PIN TUC 500) or EPA-DHA 720 by Metagenics. Natural sources include salmon, tuna, or other fatty fish.
 
Resveratrol – this is a powerful antioxidant.You can’t stop the clock, but you can slow it down. This chemical, found in the skin of grapes, seems to interact directly with genes that regulate aging. Resveratrol has been shown to promote DNA repair in animals, enhance bloodflow to people’s brains, and halt the growth of prostate-cancer and colon-cancer cells.
Dr. Tucker’s pick: Resveratin by XYMOGEN. (call 1-800-647-6100 to order. Use PIN TUC 500). Natural sources include red wine and red grape juice.
 
EGCG – this is an anti-oxidant in green tea. Men who took green-tea extract burned 17 percent more fat after moderate exercise than those taking placebos, according to one study. It has also been shown to help prevent cancer and can improve heart health.
Dr. Tucker’s pick:  Celepro by Metagenics. I love Celepro because it supports healthy cellular aging. It contains green tea leaf extract, D-Limonene, Lycopene & Turmeric. This combination offers protection against free radicals.
 
Multivitamin/mineral – every guy should be on a comprehensive, high qualty multivitamin/mineral. My recommendation for idiot proofing what you should take is the Wellness Essentials for Men packets by Metagenics. These packets contain the Tribulus, EPA-DHA, zinc, quercetin, E, B’s, etc that all of us guys need. Don’t mess around, start taking a good quality supplement like this one offered by Metagenics.
 
Bonus – Probiotics are healthy bacteria that crowd out the disease-causing bad bacteria in your gut. These address problems caused by antibiotics use, chemotherapy, irritable bowel syndrome, and support healthy immune function.
 
 

 

 

 

 

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CoQ10 is vital

By 30 Aug, 2010 Healthy Aging, Nutrition , , , ,

Along with my multivitamins, minerals, and fish oils, CoQ10 is another supplement I take every day. CoQ10 has valid research that it is a powerful cancer fighter. Researchers in Tokyo gave rats a carcinogen that promotes colon cancer. The rats were divided into three groups. One group was fed a regular diet. The second group got a low dose of CoQ10. The third got a medium dose. 

Both of the groups that received CoQ10 had reductions in abnormal crypts (an early sign of colon cancer) of up to 77%. Ultimately, the results of this study suggested that CoQ10 held cancer in check even when exposed to this carcinogen.

Researchers in Denmark studied a group of breast cancer patients. They gave them CoQ10 plus a combination of other antioxidants and essential fatty acids. The result? The entire group had a partial remission of the cancer. But here’s where things get very interesting…Two of the patients received larger doses of CoQ10 (390 mg). Their tumors disappeared. Here’s what the researchers said regarding one of the patients: “After three months, the patient was in excellent clinical condition and there was no residual tumor tissue.”

Remarkable isn’t it?

Another study done at the University of Texas at Austin documented 10 cases of cancer patients who unexpectedly survived when treated with CoQ10. It works by blocking the free radicals that can ultimately damage the DNA in your cells. It also helps re-energize the immune system cells that get suppressed by cancer. It restores their ability to fight back and attack the cancer cells.

The only natural source of CoQ10 is red meat, especially organ meat. But today’s commercially-raised, grain-fed beef is a poor source. Even worse, many popular drugs — especially cholesterol-lowering drugs like statins — cause your levels of CoQ10 to plunge. 

I recommend getting 50-100 mg of the CoQ10 daily. I use Nanocell Q by Metagenics. Order @ www.DrJeffreyTucker.meta-ehealth.com

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CoQ10 & Statin Medication

By 19 Jul, 2010 Blog, Healthy Aging, Nutrition , , , , , , , , , , ,

I was teaching a rehab course this past weekend and all but two or three doctors out of a group of sixty did not know the many health benefits of taking Coenzyme Q10 (CoQ10). They did not know that if a patient is on a statin medication, they are at risk of being deficient and having lowered CoQ10. CoQ10 is responsible for neurological health, increased energy, improved metabolism, weight loss, cell protection, and better cardiovascular health.1-4

Heart health … according to the Journal of Cardiovascular Pharmacology, a number of clinical studies have found CoQ10 promotes cardiovascular health.5

Blood sugar … an Australian study showed that patients who took CoQ10 were able to maintain blood sugar levels that are already within the normal range.6

Vision …taking CoQ10 for a year helped one study group see more clearly.7

Cognition … an animal study performed at Johns Hopkins University found that CoQ10 supplementation improves learning and memory.7

Bronchial Health … researchers in Texas found CoQ10 promotes bronchial health.7

Gum health … CoQ10 can improve gum and oral health.7

Clear-headed comfort … in one study, more than 6 out of 10 patients treated with CoQ10 daily reported feeling more clear-headed comfort.7

Oxidative stress … CoQ10 is a powerful antioxidant, eliminating the free radicals that can cause damage to cell membranes and mitochondria.3

Skin care … a German study shows that CoQ10 can help reduce wrinkles and protect skin from the damaging effects of too much exposure to sunlight.8

Comments: I recommend NanoCell-Q by Metagenics. It is highly absorbable and comes in a delicious, natural orange flavor liguid.

 

1″CoQ10 Health Benefits” September 1, 2008. http://tinyurl.com/5qjq6
2Hemmi N. Bhagava and Raj K. Chopra. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. Volume 7, Supplement 1, June 2007, Pages S78-S88 
3William Fallon. “Has Your CoQ10 Become Obsolete?” January 2007. Life Extensions Magazine.
4Super Ubiquinol CoQ10. September1, 2008. http://www.lef.org/Vitamins-Supplements/Item01226/Super-Ubiquinol-CoQ10-100-mg-60-softgels.html
5http://www.cardiovascularpharm.com/pt/re/jcardiopharm/abstract.00005344-199701000-0003.htm;jsessionid=LtLGbKwm1nC2HGTJJjKQ11qGYTt5n9Ds9p2gg9Q2Bv8qnkLdngY2!2126095447!181195629!8091!-1
6Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control in a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
7http://www.nutraingredients-usa.com/layout/set/print/content/view/print/151477
8http://www.ncbi.nlm.nih.gov/pubmed/10416055

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BP Drops when Sugary Drinks Are Reduced

By 25 May, 2010 Blog, Nutrition, Treatment , , , , , , , , , , , , , , ,

Cutting down on sugar-sweetened soft drinks was associated with a drop in blood pressure, researchers found. In a cohort of U.S. adults, those who reduced daily intake of the beverages saw a significant drop in both systolic and diastolic blood pressure.

full story http://www.medpagetoday.com/Cardiology/Hypertension/tb/20264

Many clients with High Blood Pressure are helped by eating a low-glycemic-index dietary food plan and exercise program while incorporating medical foods and nutritional supplements. A low glycemic diet is more effective than a low fat diet in treating obesity, insulin resistance, dyslipidemia, cardiovascular disease and type-2 diabetes.

The specific medical food I use is called UltraMeal® Plus 360 — 2 scoops twice daily
UltraMeal Plus 360 is a medical food formulated to provide specialized, multi-mechanistic
nutritional support for patients with metabolic syndrome and cardiovascular disease by supplying a combination of acacia extract, reduced iso-alpha acids (RIAA), plant sterols, and heart-healthy soy protein and isoflavones.

EPA-DHA Extra Strength® — 2 to 4 softgels twice daily. This is a concentrated and stabilized purity-certified, Omega-3 Fatty Acids

Nano Cell Q10— 1-2 tablespoons daily. Nano Cell Q10 is all natural coenzyme Q10 (CoQ10) manufactured to achieve exquisite quality, purity, and bioavailability. COQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. Deficiency is also implicated in increased incidence of cataracts, neoplasia, peripheral neuropathies, and some psychiatric disturbances.
ORDER these products by clicking on the Metagenics link

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